|
KMID : 0352819930090010071
|
|
Kosin Medical Journal
1993 Volume.9 No. 1 p.71 ~ p.80
|
|
|
Effect of GnRH agonist Treatment on Leiomyoma -A study on the clinical effect and ultrastructural hanges-
|
|
|
|
|
Abstract
|
|
|
Adlninistration of gonadotropin hormone-releasing hormone(GnRH) agonist, through a process of pituitary desensditization of receptors, inhibits the secretion of gonadotropin and sex-steroids and induces a reversible suppression of gonadal
activity.
This
approach can be used as an effective endocrine therapy for some hormone-dependent tumors. We have used GnRH agonist, for the treatment of four patients with uterine leiomyomas, thereafter myometomywas performed in all cases
To assess the effect of treatment with GNRH agonist, ultrastructural changes of the tumor cells of leiomyoma are studied, along with measurement of changes in serum hormone levels (SH, FSH, and E2) and the sizes of the neoplasm.
Elecron microscop0ic findings of myoma cells after the use of GnRH agonist incluede the following: increased mitochondria, swelling of mitochondria with loss of cristae, clumping of nuclear chromatin, dilation of endoplasmic reticu lum and
perinuclear
vacuolation, and loss of myofilaments.
The use of GnRH agonist may be effective in reducing the size of a myoma considerably by primarily inducing medical hypophysectomy and would allow easier surgical removal
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|